The Side Effects of Taking Cialis and Alcohol

WRITTEN BY:

Amanda Stevens, BS

Medical Review by:

Dr. Po Chang Hsu MD, MS

Updated On: Apr 7, 2025
Last Medically Reviewed on: April 7, 2025
an open hand holding a single white pill; can you mix cialis and alcohol?
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    Mixing Cialis (tadalafil) and alcohol can lead to potentially dangerous side effects that many people aren’t aware of. When these substances are combined, they can cause increased dizziness, headaches, and significant drops in blood pressure. Cialis and alcohol work as vasodilators, widening blood vessels and increasing blood flow throughout the body. This combined effect can intensify side effects like flushing, rapid heartbeat, and light-headedness. Understanding these interactions is crucial for anyone taking erectile dysfunction medication to make safer choices about alcohol consumption.

    Key Points

    • Cialis contains tadalafil, a medication that increases blood flow to treat erectile dysfunction and can remain effective for up to thirty-six hours.
    • Combining Cialis and alcohol creates serious health risks as both substances lower blood pressure and can lead to dangerous hypotension.
    • Potential dangers include severe blood pressure drops, increased side effects, reduced medication effectiveness, heart complications, and liver strain.
    • People taking Cialis should follow specific guidelines like taking it as prescribed, avoiding grapefruit, limiting alcohol, monitoring for side effects, and seeking help for alcohol use disorder if needed.

    What is Cialis?

    Cialis is a prescription medication containing tadalafil, which belongs to a class of drugs called phosphodiesterase 5 (PDE5) inhibitors.[1] These medications work by increasing blood flow to the penis during sexual stimulation, helping men with erectile dysfunction achieve and maintain erections.

    Unlike similar medications that last four to six hours, Cialis can remain effective for up to thirty-six hours, earning it the nickname “the weekend pill.”[2] This longer duration allows for more spontaneity in intimate relationships without requiring precise medication timing.

    Tadalafil, the active ingredient in Cialis, is also prescribed under different brand names to treat pulmonary arterial hypertension and benign prostatic hyperplasia. For erectile dysfunction, it comes in various dosages, ranging from two and a half to twenty milligrams.

    Is It Dangerous to Mix Alcohol and Cialis?

    Mixing alcohol and Cialis creates potentially serious health risks due to their combined effects on blood pressure.[3] Both substances act as vasodilators that relax blood vessels and lower blood pressure, leading to dangerous hypotension when used together. This combination may overwhelm the cardiovascular system, especially in people with existing heart conditions or those taking other medications that affect blood pressure.

    The severity of these risks depends on several factors, including the amount of alcohol consumed, the dosage of Cialis taken, a person’s tolerance, and underlying health conditions. While small amounts of alcohol might be tolerable for some people taking Cialis, providers generally recommend against combining these substances due to unpredictable effects and the inability to determine a universally safe threshold for consumption.[4]

    What Are the Potential Risks and Interactions?

    Combining Cialis and alcohol can lead to several concerning interactions that might impact health and safety. The primary concern stems from how both substances affect blood vessels and blood pressure, creating a compounding effect that intensifies potential dangers:[5]

    • Severe blood pressure drops can cause fainting, dizziness, and, in serious cases, insufficient blood flow to vital organs.
    • Increased side effect intensity, including headaches, flushing, and digestive discomfort beyond what either substance might cause individually.
    • Impaired judgment from alcohol might lead to incorrect dosing or forgetting that Cialis was already taken.
    • Reduced effectiveness of the medication, potentially defeating the purpose of taking it in the first place.
    • Heart complications are particularly common for those with pre-existing cardiovascular conditions or who take other medications affecting heart function.
    • Liver strain, as both substances require liver processing.

    Are There Drug-Drug Interactions?

    man drinking alcohol at a bar

    Drug-drug interactions occur when one medication affects how another medication works in the body. These interactions can change the effectiveness of medications, increase the risk of side effects, or create entirely new adverse reactions. The body processes drugs through various pathways, particularly in the liver and kidneys. When multiple medications compete for the same pathways, they can interfere with each other’s metabolism and elimination.

    Cialis does have several important drug-drug interactions beyond just alcohol.[6] It interacts significantly with nitrate medications used for chest pain (such as nitroglycerin), creating dangerous drops in blood pressure that can be life-threatening. Other concerning interactions include certain antibiotics, antifungals, HIV protease inhibitors, and other medications for erectile dysfunction. Alpha-blockers prescribed for prostate conditions or high blood pressure can also interact with Cialis, potentially causing dizziness, fainting, or other cardiovascular complications when used together.

    Are There Specific Guidelines or Precautions for People Taking Cialis?

    For those prescribed Cialis, following specific guidelines can maximize the benefits while reducing the risk of adverse effects. The medication works optimally when taken as directed, with several important precautions to consider for safety and effectiveness:

    • Take as your doctor prescribes, following exact dosage instructions rather than adjusting independently.
    • Plan accordingly for sexual activity, recognizing that while Cialis offers a longer window of effectiveness, timing still matters.
    • Avoid grapefruit products as they can interfere with how your body processes tadalafil, potentially increasing side effects.
    • Inform all healthcare providers about your use of Cialis to prevent dangerous drug interactions with new prescriptions.
    • Monitor for side effects, such as back pain, muscle aches, headaches, or vision changes, that may require medical attention.
    • Use caution with alcohol by limiting consumption to minimal amounts, if any, when taking Cialis.
    • Store it properly away from moisture and heat, keeping the medication in its original container.
    • Seek emergency care for erections lasting more than four hours, as this requires immediate medical intervention.

    How Can People Make Informed Choices Regarding Alcohol and Medication Use?

    Making informed choices about alcohol consumption while taking Cialis requires understanding both substances and consulting with appropriate medical professionals. Knowledge empowers people to make safer decisions that protect their health while managing their medical conditions effectively.

    Steps to make more informed choices include:

    • Consult healthcare providers about specific guidelines relating to your prescription, health conditions, and personal risk factors.
    • Read medication guides thoroughly, especially warnings, contraindications, and interaction information.
    • Ask pharmacists for clarification on medication instructions, as they can provide accessible explanations about potential interactions.
    • Consider timing carefully if occasional alcohol consumption is approved by your doctor, allowing sufficient separation between drinking and taking medication.
    • Start with minimal amounts if drinking is permitted, observing how even small quantities affect you when combined with your medication.
    • Know your body and recognize that individual responses to medications and alcohol vary based on genetics, weight, age, and overall health.
    • Plan social situations so you can make comfortable choices about alcohol without feeling pressured in the moment.
    • Explore non-alcoholic alternatives that allow participation in social drinking situations without the health risks.

    A Word About Alcohol Use Disorder

    Alcohol use disorder is a chronic health condition characterized by an inability to stop or control alcohol consumption.[7] This disorder affects millions of people across different demographics and can significantly complicate medication management, including Cialis use. When someone with AUD takes medications like tadalafil, risks increase substantially due to unpredictable drinking patterns and the potential for dangerous interactions.

    Help is available for anyone concerned about their relationship with alcohol. Primary care physicians can provide initial screenings, referrals, and treatment recommendations. Support groups, both in-person and online, offer community and understanding from others experiencing similar challenges. Various levels of care exist, from outpatient counseling to intensive residential programs, allowing treatment to match individual needs. 

    Reaching out for help takes courage and determination – and recovery is possible from drug and alcohol use. Contact us today to learn more. 

    Frequently Asked Questions About Cialis and Alcohol

    How long should I wait after taking Cialis (tadalafil) before I can drink alcohol? Chevron Down
    Can even moderate alcohol use affect how Cialis works for erectile dysfunction? Chevron Down
    How do drug interactions between Cialis, alcohol, and other medications or supplements increase health risks? Chevron Down
    What are the treatment options if someone experiences side effects after combining Cialis and alcohol? Chevron Down
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